Cox, C.A.†; Pimentel, E.B.†; Miller, B.R.; Nesbitt, D.J.; LeMonds, J.L.; Hartman, E.M.; Hancock, T.A.; Kennedy, R.T.; Coon, J.J.; Sigman, M.S.; Martell, J.D. DNA-Scaffolded Ultrahigh-Throughput Reaction Screening. Submitted. (†Co-first authors, listed alphabetically)
ChemRxiv preprint: https://chemrxiv.org/engage/chemrxiv/article-details/68991ed623be8e43d6ac4cce
Fang, S.; Acevedo, L.D.; Solivais, A.; Zhou, X.; Patil, S.S.; Delfosse, E.S.; Yin, H.; Frey, B.L.; Chapman, E.R.; Smith, L. M.; Martell, J.D. Directed Evolution of APOX for Proximity Labeling Using Phenols with High Redox Potentials. Submitted.
ChemRxiv preprint: https://chemrxiv.org/engage/chemrxiv/article-details/68e27cccbc2ac3a0e07d8536
Ogorek, A.N.†; Pani, S.†; Mertick-Sykes, E.J.; Momirov, J.; Lao, Y.; Mejia, F.B.; Chan, R.S.; Huang, X.; Dickinson, B.C.*; Martell, J.D.* Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. ACS Central Science, 2026 (ASAP). (†Co-first authors, listed alphabetically. *Corresponding authors). https://pubs.acs.org/doi/10.1021/acscentsci.5c01746
Martell, J.D.; Pimentel, E.B.; Ogorek, A.N.; Hartman, E.M.; Cox, C.A. DNA-Scaffolded Catalysis (Review Article). Trends Chem., 2025, 7, 900–915.
Shareable full-text link (until end of 2025): https://authors.elsevier.com/a/1m43W9CpcYeETH
Chung, J.C.; Hartman, E.M.; Mertick-Sykes, E.J.; Pimentel, E.B.; Martell, J.D. Hyper-Expandable Cross-Linked Protein Crystals as Scaffolds for Catalytic Reactions. ACS Appl. Mater. Interfaces, 2025, 17, 311–321. https://pubs.acs.org/doi/full/10.1021/acsami.4c15051
Zhou, X.; Martell, J.D. DNA-Directed Activation of Photocatalytic Labeling at Cell–Cell Contact Sites. ACS Chem. Biol., 2024, 19, 1935–1941. https://pubs.acs.org/doi/full/10.1021/acschembio.4c00515
Cribari, M.A.; Unger, M.J.; Unarta, I.C.; Ogorek, A.N.; Huang, X; Martell, J.D. Ultrahigh-Throughput Directed Evolution of Polymer-Degrading Enzymes Using Yeast Display. J. Am. Chem. Soc., 2023, 145, 27380–27389. https://pubs.acs.org/doi/10.1021/jacs.3c08291
Merrifield, J.L.; Pimentel, E.B.; Peters-Clarke, T.M.; Nesbitt, D.J.; Coon, J.J.; Martell, J.D. DNA-Compatible Copper/TEMPO Oxidation for DNA-Encoded Libraries. Bioconjug. Chem., 2023, 34, 1380–1386. https://pubs.acs.org/doi/10.1021/acs.bioconjchem.3c00254
Kohn, E.M.; Konovalov, K.; Gomez, C.A.; Hoover, G.N.; Yik, A.K.; Huang, X.; Martell, J.D. Terminal Alkyne-Modified DNA Aptamers with Enhanced Protein Binding Affinities. ACS Chem. Biol., 2023, 18, 1976–1984. https://pubs.acs.org/doi/10.1021/acschembio.3c00183
Ogorek, A.N.; Zhou, X.; Martell, J.D. Switchable DNA Catalysts for Proximity Labeling at Sites of Protein–Protein Interactions. J. Am. Chem. Soc., 2023, 145, 16913–16923. https://pubs.acs.org/doi/full/10.1021/jacs.3c05578
Cox, C.A.; Ogorek, A.N.; Habumugisha, J.P.; Martell, J.D. Switchable DNA Photocatalysts for Radical Polymerization Controlled by Chemical Stimuli. J. Am. Chem. Soc., 2023, 145, 1818–1825. https://pubs.acs.org/doi/full/10.1021/jacs.2c11199
Cribari, M.A.; Unger, M.J.; Martell, J.D. A Horseradish Peroxidase–Mediator System for Benzylic C–H Activation. ACS Catalysis, 2022, 12, 12246-12252. https://pubs.acs.org/doi/full/10.1021/acscatal.2c03424
Pimentel, E.B.; Peters-Clarke, T.M.; Coon, J.J.; Martell, J.D. DNA-Scaffolded Synergistic Catalysis. J. Am. Chem. Soc., 2021, 143, 21402–21409. https://doi.org/10.1021/jacs.1c10757.
Stowe, R.L.; Esselman, B.J.; Ralph, V.R.; Ellison, A.J.; Martell, J.D.; DeGlopper, K.S.; Schwarz, C.E. Impact of Maintaining Assessment Emphasis on Three-Dimensional Learning as Organic Chemistry Moved Online. J. Chem. Educ., 2020, 97, 2408–2420. https://doi.org/10.1021/acs.jchemed.0c00757.
PRIOR TO UNIVERSITY OF WISCONSIN-MADISON
Kim, E.J.; Siegelman, R.L.; Jiang, H.Z.H.; Forse, A.C.; Lee, J.-H.; Martell, J.D.; Milner, P.J.; Falkowski, J.M.; Neaton, J.B.; Reimer, J.A.; Weston, S.C.; Long, J.R. Cooperative Carbon Capture and Steam Regeneration with Tetraamine-Appended Metal–Organic Frameworks. Science, 2020, 369, 392–396.
Martell, J.D.†; Milner, P.J.†; Siegelman, R.L.; Long, J.R. Kinetics of Cooperative CO2 Adsorption in Diamine-Appended Variants of the Metal–Organic Framework Mg2(dobpdc). Chem. Sci., 2020, 11, 6457–6471. (†Co-first authors.)
Han, Y.; Branon, T.C.; Martell, J.D.; Boassa, D.; Shechner, D.; Ellisman, M.H.; Ting, A.Y. Directed Evolution of Split APEX2 Peroxidase. ACS Chem. Biol., 2019, 14, 619–635.
Forse, A.C.; Milner, P.J.; Lee, J.-H.; Redfearn, H.N.; Siegelman, R.L.; Martell, J.D.; Dinakar, B.; Porter-Zasada, L.B.; Gonzalez, M.I.; Neaton, J.B.; Long, J.R.; Reimer, J.A. Elucidating CO2 Chemisorption in Diamine-Appended Metal–Organic Frameworks. J. Am. Chem. Soc., 2018, 140, 18016–18031.
Forse, A.C.; Gonzalez, M.I.; Siegelman, R.L.; Witherspoon, V. J.; Jawahery, S.; Mercado, R.; Milner, P.J.; Martell, J.D.; Smit, B.; Blümich, B.; Long, J.R.; Reimer, J.A. Unexpected Diffusion Anisotropy of Carbon Dioxide in the Metal–Organic Framework Zn2(dobpdc). J. Am. Chem. Soc., 2018, 140, 1663–1673.
Milner, P.J.; Martell, J.D.; Siegelman, R.L.; Gygi, D.; Weston, S.C.; Long, J.R. Overcoming multiple CO2 adsorption steps while minimizing water co-adsorption in bulky diamine-appended variants of Mg2(dobpdc). Chem. Sci., 2018, 9, 160–174.
Martell, J.D.; Porter-Zasada, L.B.; Forse, A.C.; Siegelman, R.L.; Gonzalez, M.I.; Oktawiec, J; Xu, J; Srebo-Hooper, M.; Runčevski, T.; Milner, P.J.; Colwell, K.A.; Autschbach, J.; Reimer, J.A.; Long, J.R. Enantioselective Recognition of Ammonium Carbamates in a Chiral Metal–Organic Framework. J. Am. Chem. Soc., 2017, 139, 16000–16012.
Milner, P.J.; Siegelman, R.L.; Forse, A.C.; Gonzalez, M.I.; Runčevski, T; Martell, J.D.; Reimer, J.A.; Long, J.R. A Diaminopropane-Appended Metal–Organic Framework Enabling Efficient CO2 Capture from Coal Flue Gas via a Mixed Adsorption Mechanism. J. Am. Chem. Soc., 2017, 139, 13541–13553.
Martell, J.D.; Deerinck, T.J.; Lam, S.S.; Ellisman, M.H.; Ting, A.Y. Electron Microscopy Using the Genetically Encoded APEX2 Tag in Cultured Mammalian Cells. Nature Protocols, 2017, 12, 1792–1816.
Siegelman, R.L.; McDonald, T.M.; Gonzalez, M.I.; Martell, J.D.; Milner, P.J.; Mason, J.A.; Berger, A.H.; Bhown, A.S.; Long, J.R. Controlling Cooperative CO2 Adsorption in Diamine-Appended Mg2(dobpdc) Metal–Organic Frameworks. J. Am. Chem. Soc., 2017, 139, 10526–10538.
Martell, J.D.; Yamagata, M.; Deerinck, T.J.; Phan, S.; Kwa, C.G.; Ellisman, M.H.; Sanes, J.R.; Ting, A.Y. A Split Horseradish Peroxidase for the Detection of Intercellular Protein-Protein Interactions and Sensitive Visualization of Synapses. Nature Biotechnology, 2016, 34, 774–780. (Highlighted in Nature Methods)
Lam, S.S.; Martell, J.D.; Kamer, K.J.; Deerinck, T.J.; Ellisman, M.H.; Mootha, V.K.; Ting, A.Y. Directed Evolution of APEX2 for Electron Microscopy and Proximity Labeling. Nature Methods, 2015, 12, 51–54.
Dwyer, D.J.; Yang, J.H.; Belenky, P.; MacDonald, C.I.; Martell, J.D.; Chan, C.T.; Kobayashi, N.; Lobritz, M.A.; Braff, D.; Schwarz, E.G.; Ye, J.D.; Patti, M.; Vercruysse, M.; Ralifo, P.S.; Allison, K.R.; Khalil, A.S.; Ting, A.Y.; Walker, G.C.; Collins, J.J. Antibiotics Induce Redox-Related Physiological Alterations as Part of their Lethality. PNAS, 2014, 111, E2100–E2109.
Rhee, H.-W.; Zou, P.; Udeshi, N.D.; Martell, J.D.; Mootha, V.K.; Carr, S.A.; Ting, A.Y. Proteomic Mapping of Mitochondria in Living Cells via Spatially-Restricted Enzymatic Tagging. Science, 2013, 339, 1328–1331. (Highlighted in Nature Methods and in Nature Reviews Molecular Cell Biology)
Martell, J.D.; Deerinck, T.J.; Sancak, Y.; Poulos, T.L.; Mootha, V.K.; Sosinsky, G.E.; Ellisman, M.H.; Ting, A.Y. Engineered ascorbate peroxidase as a genetically-encoded reporter for electron microscopy. Nature Biotechnology, 2012, 30, 1143–1148. (Highlighted in Nature Methods)
Doukov, T.; Li, H.; Sharma, A.; Martell, J.D.; Soltis, S.M.; Silverman, R.B.; Poulos, T.L. Temperature-dependent spin crossover in neuronal nitric oxide synthase bound with the heme-coordinating thioether inhibitors. J. Am. Chem. Soc., 2011, 133, 8326–8334.
Martell, J.D.; Li, H.; Doukov, T.; Martasek, P.; Roman, L.J.; Soltis, M.; Poulos, T.L.; Silverman, R.B. Heme-coordinating inhibitors of neuronal nitric oxide synthase. Iron–thioether coordination is stabilized by hydrophobic contacts without increased inhibitor potency. J. Am. Chem. Soc., 2010, 132, 798–806.